Scientists have grown a human retina from scratch in the lab

Scientists at the Johns Hopkins University, have fabricated human retinas from scratch in the lab, to know how cells that enable people to see in color are made.

Image Credit: Dave Schmelick

Scientists at the Johns Hopkins Universityhave fabricated human retinas from scratch in the lab, to know how cells that enable people to see in color are made. The work is expected to establishes the framework to create treatments for eye infections, for example, visual weakness and macular degeneration.

“Everything we examine looks like a normal developing eye, just growing in a dish. You have a model system that you can manipulate without studying humans directly," said Robert Johnston, a developmental biologist at Johns Hopkins University.
Scientists explored how a cell’s fate is determined—what happens in the womb to turn a developing stem cell into a certain type of cell. They particularly focused on the cells that allow people to see blue, red and green i.e. the three cone photoreceptors in the human eye.
Over months, as the cells grew in the lab and became full-blown retina tissue, the team found the blue-detecting cells materialized first, followed by the red- and green-detecting ones. In both cases, they found the key to the molecular switch was the ebb and flow of thyroid hormone. Specifically, the level of this hormone wasn’t controlled by the thyroid gland, which of course isn’t in the lab dish, but the eye tissue did by itself.
Understanding how the amount of thyroid hormone dictated whether the cells became blue or red and green receptors, the team was able to manipulate the outcome, creating retinas that if they had been part of a complete human eye would only see blue, and ones that could only detect green and red.
“Trichromatic color vision differentiates us from most other mammals. Our research is really trying to figure out what pathways these cells take to give us that special color vision," said Lead author Kiara Eldred, a graduate student of Johns Hopkins University.
The study suggests that thyroid hormone is essential for creating red-green cones provides insight into why pre-term babies, who have lowered thyroid hormone levels as they are lacking the maternal supply, have a higher incidence of vision disorders.
Eldred said, “If we can answer what leads a cell to its terminal fate, we are closer to being able to restore color vision for people who have damaged photoreceptors. This is a really beautiful question, both visually and intellectually—what is it that allows us to see color?”
Johnston said, “What’s exciting about this is our work establishes human organoids as a model system to study mechanisms of human development. What’s really pushing the limit here is that these organoids take nine months to develop just like a human baby. So what we’re really studying is fetal development.”
The research is published in the journal Science.
Reference: Tech Explorist

Subscribe Newsletter

Name

Health,34,Nature,6,Science,73,Space,57,Technology,93,
ltr
item
Scien-Tech News: Scientists have grown a human retina from scratch in the lab
Scientists have grown a human retina from scratch in the lab
Scientists at the Johns Hopkins University, have fabricated human retinas from scratch in the lab, to know how cells that enable people to see in color are made.
https://3.bp.blogspot.com/-KAs7HQ2B2p8/W8Rnt9VcZwI/AAAAAAAAA7U/G6yoFBPv3OE7TSTCZ8wAow4TRRGA8fc9QCLcBGAs/s400/lab-eyes-696x392.jpg
https://3.bp.blogspot.com/-KAs7HQ2B2p8/W8Rnt9VcZwI/AAAAAAAAA7U/G6yoFBPv3OE7TSTCZ8wAow4TRRGA8fc9QCLcBGAs/s72-c/lab-eyes-696x392.jpg
Scien-Tech News
https://www.scien-technews.com/2018/10/scientists-have-grown-a-human-retina-from-scratch-in-the-lab.html
https://www.scien-technews.com/
https://www.scien-technews.com/
https://www.scien-technews.com/2018/10/scientists-have-grown-a-human-retina-from-scratch-in-the-lab.html
true
8514685892313606732
UTF-8
Loaded All Posts Not found any posts VIEW ALL Readmore Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS PREMIUM CONTENT IS LOCKED STEP 1: Share. STEP 2: Click the link you shared to unlock Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy